Optimal design of size, shape, topology, static scheme and prestressing of structural systems by mathematical programming and artificial intelligence methods (heuristic techniques, genetic algorithms, evolutionary processes). Optimization methods for structural detailing (generation of strut-and-tie and stringer-panel models). Life-cycle optimization of structures under scheduled maintenance. Optimal seismic design of precast structures and connection systems. Testing of novel connectors (anchors) under static and seismic loads. Testing of structural elements, parts of structures and connections made with new materials (structural glass, high performance concrete, laminated wood) under static and variable loads, and environmental actions. For historic structures: mechanical and numerical modeling of survey data; selection of intervention strategies compatible with the principles of conservation. Development of special operative techniques, such as controlled injections, structural repointing, compatible use of composite materials. Evaluation of the effectiveness of the interventions.